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Hispanics Benefit from Cholesterol-Lowering Statins
THURSDAY, March 2 (HealthDay News) -- Two kinds of cholesterol-lowering statin drugs -- Crestor and Lipitor -- may reduce important heart disease risk factors in Hispanic Americans, new research shows.
The findings were presented Thursday at the American Heart Association's annual conference on Cardiovascular Disease Epidemiology and Prevention, in Phoenix. The study was funded by AstraZeneca, the maker of Crestor.
The study included 635 volunteers, whose blood levels of C-reactive protein (CRP) and LDL "bad" cholesterol were measured before and after treatment. CRP is a marker of inflammation, and high levels of CRP correlate with increased risk of coronary heart disease.
All the volunteers had LDL levels of 130 milligrams per deciliter at the start of the study, which put them at high risk for having a coronary event within the next 10 years.
The volunteers were divided into four groups. One group received 10 milligrams of Lipitor, made by Pfizer Inc., daily for six weeks; a second group received 20 milligrams of Lipitor; the third group received 10 milligrams of Crestor; and the fourth group received 20 milligrams of Crestor.
"LDL levels fell significantly in all four statin-treatment groups after six weeks. Crestor, at both doses, reduced LDL significantly more than Lipitor did at the same dose. Both the drugs had similar effects on the participants' CRP levels," study author Dr. Ramon Luis Lloret, cardiologist and president of the Cardiovascular Center of South Florida, said in a prepared statement.
Drug companies spend more on marketing than R&D
The top 10 drug companies spent nearly three times more on marketing, public relations and administration than they did on research and development.
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Pending Generic Drug Applications
If a patent is listed in the "Orange Book," an applicant seeking approval for an ANDA must submit a certification to the patent. Even an applicant ... Read more >
Definition:
FDA considers drug products to be pharmaceutical equivalents if they meet these three criteria: they contain the same active ingredient(s), they are of the same dosage form and route of administration and they are identical in strength or concentration.
Medication Guide
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A medication guide contains information for patients' understanding of how to safely use a drug product.
Patient Package Insert (PPI)
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A patient package insert contains information for patients' understanding of how to safely use a drug product.
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